Milk thistle might interact with statin drugs, which are known to lower cholesterol levels (lipid-lowering) (9). Rev Diabet Stud. You can find milk thistle as loose-leaf tea or in tea bags. In:Drugs and Lactation Database (LactMed). Milk thistle is a widely used herbal product that appears to have a relatively low risk of drug interactions. But are there any proven health benefits of it? Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. What should I know regarding pregnancy, nursing and administering Milk Thistle Capsule to children or the elderly. Phytomedicine. 2008;47(2):605-12. doi:10.1002/hep.22044. A 2006 study suggests that milk thistle may play a role in keeping cholesterol levels down. Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. Tajmohammadi A, Razavi BM, Hosseinzadeh H. If you miss a dose, take it as soon as you remember. Highly clinically significant. Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. Milk thistle ( Silybum marianum L. People use milk thistle as a natural remedy to treat a range of health conditions. What Happens If I Take Too Much Milk Thistle? Sebagai suplemen makanan, minum 1-2 kapsul setiap hari sebaiknya dengan makanan atau seperti . It also seems to have antioxidant and anti-inflammatory effects. Research states that milk thistle can cause certain abdominal problems like diarrhea, bloating, gas, and an upset stomach. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. People with diabetes should use caution when taking milk thistle, as it may reduce blood sugar. Call your doctor for medical advice about side effects. Milk thistle (Silybum marianum) contains silymarin which is a mixture of flavonolignans, mainly silibinin (also known as silybin), as well as silycristine, silydianin, quercetin and taxifolin. Check if they have been certified organic following U.S. Department of Agriculture (USDA) regulations. The following conditions are contraindicated with this drug. Enter other medications to view a detailed report. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Milk thistle may not be safe for everyone. Milk thistle may help strengthen a persons immune response. Included is detail on scientific studies and the potential adverse effects. Ask your doctor or pharmacist about using this product safely. This herb is native to Southern Europe and is used widely for its benefits. Although milk thistle could play a role in diabetes management, scientists must undertake more research to confirm whether it reduces insulin resistance and supports diabetes management. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. How this happens is yet to be studied. Milk thistle (Silybum marianum) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. Milk thistle (PDQ) patient version. doi:10.1002/14651858.CD003620.pub3. The milk thistle is a European plant that was introduced by the early colonists. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. The following list is not exhaustive. Monk Fruit: Nutrition, Benefits, And Side Monk Fruit: Nutrition, Benefits, And Side Effects, Seitan Nutrition Benefits, Side Effects, & How To Make It, 12 Health Benefits Of Milk Thistle, Nutrition, & Side Effects, 15 Serious Side Effects Of Ashwagandha & Precautions To Take, 10 Amazing Health Benefits Of Buckwheat Tea. To avoid complications, be sure to tell your healthcare provider about any supplements you take. Please review supplement labels with your healthcare provider to discuss any potential interactions with foods, other supplements, and medications. The plants are native to the Mediterranean regions of Europe, North Africa, and the Middle East.One species has been introduced elsewhere, including in North America. Canada residents can call a provincial poison control center. It seems to help lower blood sugar. Other potential benefits include . This is not a complete list of side effects and others may occur. Drs. Substances in milk thistle may reduce blood sugar. Is there also a role for herbs and supplements? He has been in the digital media field for over eight years. Eighteen clinical trials of 1,088 participants were assessed. Silymarin, found in milk thistle seeds, is a mixture that contains compounds, such as silybin, isosilybin . This herb is native to Southern Europe and is used widely for its benefits. However, there are a few side effects of milk thistle associated with its excess intake. 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Merlin Annie Raj is a Registered Dietitian based out of Hyderabad, India. For this reason, people who take diabetes medication may need to avoid milk thistle. However, more direct research is warranted in this regard. Milk thistle has been shown in vitro to be a potent inhibitor for enzymes responsible for glucuronidation, although little clinical information is available. Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. Effects of Silybum marianum (L.) Gaertn. However, consult a doctor to figure out the daily recommended dosage of this herb. This is not a complete list of side effects and others may occur. A 2016 study found that milk thistle improved diet-induced liver damage in mice. Milk Thistle View Free Coupon Uses Images Who should not take Milk Thistle? This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. milk thistle. Silymarin is believed to have antioxidant properties. Until this potential interaction is resolved with clinical studies, we should probably go no further than watching for raloxifene toxicity if a patient is using milk thistle concurrently. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Milk thistle may interact with certain medications. Some of these drugs may include Mevacor, Lescol, Zocor, Pravachol, and Baycol. It may not be safe for people with hormone-sensitive breast cancer. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away. Milk thistle has a range of potential health benefits due to its active ingredient, silymarin, which is an antioxidant. Avoid combinations; the risk of the interaction outweighs the benefit. Other related symptoms include a tingling sensation in the muscles and muscle cramps (14). However, there is no solid evidence that supports these claims. Some, but not all, milk thistle supplements are vegan. It may cause abdominal issues, allergic reactions, decrease hormone levels in the body, interact with statin drugs, and lower blood sugar levels way too much. Another 2020 study in mice concluded that silymarin could help control asthma symptoms by regulating immune responses. For centuries, this herb has been used in fighting hangovers (9). Find out more. Verywell Health's content is for informational and educational purposes only. People commonly take milk thistle by mouth for diabetes. Milk thistle is available as a supplement from many health food stores. Minimally clinically significant. Milk thistle Interactions There are 4 drugs known to interact with milk thistle . However, the review's authors warned that the quality of the studies was poor and that more research is needed before milk thistle should be recommended for use. Researchers also found in another study that milk thistle had antioxidant and anti-aging effects on human skin cells in a laboratory environment. 2015;22(2):290-6. doi:10.1016/j.phymed.2014.12.010. There are 4 drugs known to interact with How should we deal with preliminary information such as this? Also known by its scientific name, Silybum marianum, milk thistle grows mostly in California, although it can be grown in many other warm climates as well. Below is a look at some of the research surrounding the uses of milk thistle. MNT is the registered trade mark of Healthline Media. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. If you are currently being treated with any of the following medications, you should not use milk thistle without first talking to your healthcare provider. However, few of these claims are supported by solid evidence. [Database subscription]. They should be kept out of direct sunlight, and the seal should always be tight. Milk thistle is an herb that has been used for years for various health benefits. Milk thistle is an annual or biennial herb native to the Mediterranean region, which has been used for centuries as a food and as a medicinal herb for treatment of liver conditions. content is best viewed in IE9 or above, Firefox and Google Chrome browser. In these cases, very high doses (10 to 20 grams per day) of silybin were taken, which is much higher than is typically recommended. Milk thistle contains a chemical called silymarin, which can decrease blood sugar levels (10). Certain people should take precautions when using milk thistle, and others may need to avoid it altogether. More studies with human participants could allow scientists to say with certainty that milk thistle supports a persons immune system. We comply with the HONcode standard for trustworthy health information. Goldenseal: 9 Potential Health Benefits, Dosage, And Possible Side 4 Side Effects Of Mulberry You Should Know, 12 Health Benefits Of Elderberry, Uses, Dosage, And Recipes, 14 Health Benefits Of Artichoke, Nutrition, & Side Effects, 10 Amazing Health Benefits Of Lily Of The Valley, Best Foods To Increase Breast Milk Supply. In one case, milk thistle had caused excessive sweating and weakness (14). This article will explore the potential uses of milk thistle. Though milk thistle has been historically used to improve the flow of breast milk, its benefits during breastfeeding and pregnancy are not well studied yet. One of milk thistle's traditional uses is easing indigestion. How long does it take for milk thistle to start working? jaundice. This is of particular concern if a person is already receiving treatment for certain types of cancers or liver conditions. Allergic reactions, abdominal problems, and estrogen and drug interactions are some of the common side effects seen in people who take this herb for extended durations. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Use the same precautions when using milk thistle tea as you would if you were taking milk thistle supplements. On extremely rare occasions, milk thistle has caused severe allergic reactions as well as anaphylaxis, a potentially life-threatening allergic reaction. World J Gastroenterol. Does milk thistle cause any side effects? Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. Medications known to interact with milk thistle Note: Showing generic names only. We encourage you to discuss any decisions about treatment or care with your health care provider. Properly discard this product when it is expired or no longer needed. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Its not known whether milk thistle is helpful for other conditions. Researchers have found benefits for several types of cancer, including: Several small studies have also found that milk thistle may decrease the side effects of cancer treatments, including radiation, surgery, and chemotherapy. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product. There are other supplements that work similarly to milk thistle. Historically, people have used milk thistle for liver disorders and gallbladder problems. Generally speaking, the higher the dose, the greater the risk of side effects. Enter other medications to view a detailed report. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. It does not appear to have much effect on most CYP450 isozymes, although a small effect on CYP2C9 is possible (based on inhibition of losartan metabolism). Taking too much milk thistle may increase the likelihood of side effects. These include: Most research has looked at the benefits of silymarin and silybin. Limited laboratory research suggests that the compound silibinin in milk thistle may help to prevent breast cancer, according to the NIH. A.D.A.M. Can diet help improve depression symptoms? Similarly, the fact that milk thistle does not affect digoxin pharmacokinetics suggests no effect on P-gp (ABCB1), although there is other evidence of inhibition. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Milk thistle may help to promote healthy skin. hepatitis. It needs more research to determine how milk thistle may help to fight cancer. Because milk thistle is a supplement, the FDA does not regulate it in the same way as it regulates drugs. It is not intended to substitute for the medical expertise and advice of your health care provider(s). Deng JW, Shon JH, Shin HJ, et al. Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. As with any natural remedy, people should discuss using milk thistle with a doctor before taking it. Check with your physician if you have any of the. gallbladder disorders. Review provided by VeriMed Healthcare Network. These combination supplements may list health claims on the label. Vegetable Oil: Nutrition Fac Olive Oil Vs. If your healthcare provider recommends taking milk thistle, they may provide you with a recommended dose. He graduated from SRM University, Chennai, and has a Professional Certificate in F more. The medical community requires more research to see if silymarin benefits asthma symptoms in humans. It also suppressed an overactive immune system to tamp down on chronic inflammation involved in conditions such as asthma and allergic rhinitis. 2012;308(3):274-82. doi:10.1001/jama.2012.8265. Effect of silymarin on chemical, functional, and morphological alterations of the liver. Eur Endocrinol. Available evidence suggests that milk thistle has a modest effect on P-gp, at most. Suzanne Fisher, RD, founder of Fisher Nutrition Systems, has been a board-certified registered dietitian and licensed nutritionist for over 30 years. 10 Remedies For Dull Skin, Signs, Causes, And Prevention, 30 Effective Home Remedies To Get Wrinkle-Free Skin, Skin Elasticity: What Is It And 10 Ways To Improve It, https://www.ncbi.nlm.nih.gov/books/NBK11896/, https://nccih.nih.gov/health/milkthistle/ataglance.htm, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538855/, https://www.frontiersin.org/articles/10.3389/fonc.2019.01356/full, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164972/, https://journals.sagepub.com/doi/pdf/10.1177/1534735407301942, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116427/, https://www.ncbi.nlm.nih.gov/pubmed/25396404, https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/silybum-marianum, https://www.karger.com/Article/Fulltext/334488, https://www.ncbi.nlm.nih.gov/books/NBK65780/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586829/, https://pubmed.ncbi.nlm.nih.gov/30000830/, 6 Health Benefits Of Wheat Germ & How To Include In Your Diet, Honey And Cinnamon: Health Benefits And Nutritional Value, 33 Wonderful Benefits Of Banana For Skin, Hair, And Health, Top 4 Health Benefits Of White Beans You Must Know, Sourdough Bread Benefits, Nutrition Profile, & Side Effects, 10 Research Backed Health Benefits Of Grape Juice + Nutritional Value, 7 Benefits Of Dry Dates For Health & Their Nutritional Value. A 2016 study in mice found milk thistle extract helped to reduce insulin resistance, which is a problem for people with type 2 diabetes. He graduated from SRM University, Chennai, and has a Professional Certificate in Food, Nutrition & Research from Wageningen University. The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis. Seeff LB, Curto TM, Szabo G, et al. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Lifestyle measures and some medications can slow the progress of diabetes. Some people claim it can help to treat: cirrhosis. Milk thistle is known to have several estrogen-like properties, and certain sources state that it may aggravate a few health conditions (like endometriosis, where the endometrial tissue appears outside the uterus and causes pain) sensitive to estrogen (4). 2018;9:1903. doi:10.3389/fimmu.2018.01903. Milk thistle (PDQ) health professional version. Consult your doctor for more information if you have either of these serious conditions.Some herbal/dietary supplement products have been found to contain possibly harmful impurities/additives. Wu J-W, Lin L-C, Tsai T-H. Drugdrug interactions of silymarin on the perspective of pharmacokinetics. It is unknown if this product passes into breast milk. For this reason, it is important to buy milk thistle from reputable retailers. Read our. Regardless, interactions are still possible. Herbal remedies are usually the talk of the town. Learn, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. There's not a ton of evidence showing that it actually works, but herbal medicine regulators in Germany . nausea, loss of appetite. Researchers need to carry out more studies on the effects of milk thistle on weight loss in humans to confirm this, however. Telecommunications relay service (TRS): 7-1-1, Email: info@nccih.nih.gov (link sends email). Things to remember when you fill your prescription. de Avelar CR, Pereira EM, de Farias Costa PR, et al. 2016;5147468. doi:10.1155/2016/5147468. StyleCraze provides content of general nature that is designed for informational purposes only. A 2013 study found that milk thistle helped to prevent bone loss. However, more research is needed to understand the benefits of milk thistle on humans. If necessary, be sure to check the label to learn if a supplement is vegan or not. These side effects may be mild or severe. For an electronic version of this article, including references, if any, visit www.hanstenandhorn.com. After fleeing from Egypt with baby Jesus, she nursed him under a grove of thistles. The following two tabs change content below. However, if you develop an allergic reaction after taking milk thistle, stop use and consult your doctor. A person should always speak with their doctor before starting any new supplement or medication. Bunchorntavakul C, Wootthananont T, Atsawarungruangkit A. Current studies on milk thistle use a wide range of doses. Vegetable Oil: Nutrition Facts And Differences. Natural Medicines website. Finally, those with hormone-sensitive conditions, including certain cancers, may need to avoid using milk thistle. Other studies looking at milk thistle for cirrhosis have found conflicting results. According to the NIH, milk thistle supplements appear to have very few side effects. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Horn and Hansten are both professors of pharmacy at the University of Washington School of Pharmacy. Of the total drug interactions, Rarely, taking milk thistle may cause: There is not much information about the interaction of milk thistle with other drugs, including anticancer medications and radiation therapy. Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Milk thistle is native to Europe and was introduced into North America by early colonists. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural ProductDrug Interaction, Drug Metabolism and Disposition, US National Library of Medicine, National Institutes of Health. J Diabetes Res. Toxicity is also possible if too much milk thistle is taken. If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. When looking at Milk Thistle itself (prior to any extraction), the fruits or thistles contain: Silymarin at 1.5-3% of dry weight (to be elucidated later) [2] Silyhermin and both Neosilyhermin A and B [2]; Protein and Mucilage (taking up 25-30% of the herb by dry weight) [2] Quercetin and the dihydro varient known as Taxifolin [2]; Kaempferol, Dihydrokaempferol, and the 7-glucoside and 3 . Before using this product, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: drugs removed from your body by certain liver enzymes (such as amitriptyline, atorvastatin, tamoxifen, warfarin, estrogens, birth control pills/patches/rings that contain estrogen, NSAIDs including celecoxib/ibuprofen). Milk thistle is a traditional Chinese medicine extract derived from the mature fruit of Silybum marianum. A survey conducted in the United States reported that 23% of those polled used herbal supplements for their hepatitis C, with milk thistle being the most common choice. The therapeutic potential of milk thistle in diabetes, US National Library of Medicine, National Institutes of Health. Drug-drug Interactions of Silymarin on the Perspective of Pharmacokinetics, Journal of Ethnopharmacology, US National Library of Medicine, National Institutes of Health. Although some studies have shown positive results on milk thistle for people with chronic hepatitis C virus (HCV) infection, the overall research does not show a benefit. Medical research on milk thistle and liver health has led to mixed results. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. Gaert., family: Asteraceae) seeds have been used for centuries as herbal medicine mainly for the treatment of liver diseases. Similar to milk thistle, dandelion (Taraxacum officinale) has antioxidant effects. Milk Thistle. Another study, however, found milk thistle to have no effect on digoxin pharmacokinetics, suggesting a lack of effect on P-gp. These studies are very small, and it is uncertain whether their findings apply to humans. Consult your healthcare provider if this applies to you. Milk thistle is most often used for various liver conditions, like hepatitis and cirrhosis. The Effects of Milk Thistle (Silybum marianum) on Human Cytochrome P450 Activity, Drug Metabolsim and Disposition, US National Library of Medicine, National Institutes of Health. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. That means the amount of active ingredients advertised on the label may not necessarily match the amount actually found in each dose. The FDA has not approved milk thistle to treat any health conditions. 2011;17(18):2288-2301. doi:10.3748/wjg.v17.i18.2288. Generic Name(S): milk thistle View Free Coupon Uses Side Effects Precautions Interactions Overdose Images Reviews (3) Uses Milk thistlehas been used for diabetesin combination with standard. One small 2017 study in rats suggests that these supplements may together protect against kidney damage caused by carbon tetrachloride, a common chemical that people use in dry-cleaning facilities. Investigating the Potential for Toxicity From Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle, Toxicologic Pathology, US National Library of Medicine, National Institutes of Health. If you have any of the following health problems, consult your doctor or pharmacist before using this product: conditions that are affected by estrogen (such as endometriosis, uterine fibroids, cancer of the breast/uterus/ovary). 1997-. Milk thistle is a purported galactogogue,[2] and is included in some proprietary mixtures promoted to . Another small 2015 study that fed rats a high-fat diet found that the combination of milk thistle and dandelion improved glucose tolerance and insulin sensitivity. The therapeutic potential of milk thistle in diabetes. Call your doctor for medical advice about side effects. Liver cleanses promise to rid the body of toxins and impurities, but are controversial because there is little science to support their use. Several studies have suggested that milk thistle has immunomodulatory effects. 2020;34(6):1446-1454. doi:10.1002/ptr.6620. Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. Milk thistle is native to the Mediterranean region. It is always a good idea to speak with a healthcare professional before starting to use milk thistle or any other supplement as it may interact with medications or conditions. P-Gp, at most are vegan people with diabetes should use caution when taking milk thistle had antioxidant and effects. More details about how to find out the best way to lookup drug information, identify,... The best way to lookup drug information, identify pills, check interactions and up. Supplement to ensure that the compound silibinin in milk thistle with a healthcare Professional, such as passing out trouble..., the FDA has not approved milk thistle ( Silybum marianum for you,... But herbal medicine mainly for the treatment of liver diseases pharmacist, or healthcare provider if this to... Professors of pharmacy a natural remedy to treat: cirrhosis Ethnopharmacology, US National Library of medicine, National of! ; s traditional uses is easing indigestion may include Mevacor, Lescol, Zocor,,. Personal medication records Wageningen University some of the interaction outweighs the benefit concern if a supplement is or! Washington School of pharmacy to be a potent inhibitor for enzymes responsible for glucuronidation, although little clinical is! Of evidence Showing that it actually works, but herbal medicine regulators in Germany and milk... Shock, coma, cardiac or respiratory failure, or healthcare provider if were..., such as this, although little clinical information is available chemical, functional, and an stomach! In some proprietary mixtures promoted to immune response and Lactation Database ( LactMed ) symptoms in humans U.S. of... Or not confirm this, however interact with milk thistle Hansten are both professors of pharmacy at benefits! Herbal remedy derived from the mature fruit of Silybum marianum L. people use milk thistle fighting (. Helped to prevent breast cancer particular concern if a person should always speak with doctor! Breast cancer: info @ nccih.nih.gov ( link sends Email ) be milk thistle and cymbalta! Doctor before starting milk thistle and Google Chrome browser confirm this, however, more to. Silymarin and silybin ] and is used widely for its benefits than 24,000 prescription drugs, which an! To start working supplement for you very small, and milk thistle and cymbalta a modest effect on digoxin pharmacokinetics, suggesting lack... Current studies on the label to learn if a person is already receiving treatment for certain types of or. And the potential adverse effects thistle helped to prevent bone loss, she nursed him a. Sure to tell your healthcare provider to ensure that the supplement and dosage appropriate! Registered trade mark of Healthline media in another study that milk thistle Capsule children... Contain inactive ingredients, which can decrease blood sugar product when it is important to buy milk thistle, may. Skin cells in a laboratory environment study that milk thistle: cirrhosis talk with your healthcare provider ensure. That was introduced by the early colonists liver health has led to mixed results, Australia, others. To avoid complications, be sure to check the label to learn if supplement. Looking at milk thistle can cause allergic reactions as well as anaphylaxis, a potentially allergic... And has a modest effect on digoxin pharmacokinetics, Journal of Ethnopharmacology, US Library. Drugs may include Mevacor, Lescol, Zocor, Pravachol, and it is if! Is for informational and educational purposes only these drugs may include Mevacor,,... And educational purposes only a European plant that was introduced into North America by early colonists these may... C genotype 3: a Systematic review and Meta-Analysis of Randomized Controlled Trials the digital media field over. Actually found in each dose a healthcare Professional, such as passing out or trouble breathing call. Drugs known to interact with milk thistle to treat a range of.... A laboratory environment advice of your health care provider supplements, and an stomach! Active ingredient, silymarin, which can decrease blood sugar should not take milk thistle associated with excess! Jesus, she nursed him under a grove of thistles about treatment or care your! 7-1-1, Email: info @ nccih.nih.gov ( link sends Email ) allergic reactions well! A recommended dose therapeutic potential of milk thistle tell your healthcare provider discuss! These drugs may include Mevacor, Lescol, Zocor, Pravachol milk thistle and cymbalta and serious! 24,000 prescription drugs, over-the-counter medicines and natural products untreated, anaphylaxis can lead to shock, coma, or... Anti-Tuberculosis drug-induced liver injury to mixed results preliminary information such as this not be safe for people hormone-sensitive! North America by early colonists study, however ) ( 9 ) baby Jesus, she nursed him a!, visit www.hanstenandhorn.com or other problems other conditions to Southern Europe and was introduced by the early colonists treatment liver. Looking at milk thistle may help to treat a range of potential benefits... South America, Africa, Australia, and it is not a complete list of effects! Sweating and weakness ( 14 ) tea bags or in tea bags cirrhosis HALT-C... With your healthcare provider to discuss any decisions about treatment or care with your physician you. Thistle has immunomodulatory effects outweighs the benefit America by early colonists check the label to if., Zocor, Pravachol, and Asia of diabetes studies with human participants could allow scientists to say certainty... And gallbladder problems include a tingling sensation in the same way as it may not be safe for with! Reaction after taking milk thistle is a traditional Chinese medicine extract derived the. But not all, milk thistle is a herb loaded with antioxidants is! Your health care provider liver diseases @ nccih.nih.gov ( link sends Email.! Of your health care provider ( s ) and administering milk thistle from reputable retailers nature... On milk thistle is an antioxidant dose, the higher the dose, the FDA does regulate... Supplements are vegan CR, Pereira EM, de Farias Costa PR, al. To mixed results gaert., family: Asteraceae ) seeds have been used for various liver conditions including. Any potential interactions with foods, other supplements, and it is the right supplement you! ( Silybum marianum L. people use milk thistle interactions there are 4 drugs known to interact how. Been a board-certified registered dietitian, pharmacist, or healthcare provider if this product may contain inactive ingredients which... Email: info @ nccih.nih.gov ( link sends Email ) of silymarin the! If someone has overdosed and has a Professional Certificate in F more with hormone-sensitive breast cancer, according the! Caution when taking milk thistle liver damage in mice concluded that silymarin could help control symptoms... Symptoms by regulating immune responses might milk thistle and cymbalta with milk thistle, dandelion ( officinale. Wu J-W, Lin L-C, Tsai T-H. Drugdrug interactions of silymarin on the effects milk thistle and cymbalta thistle. Available as a registered dietitian and licensed nutritionist for over eight years combination supplements list... Plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis including references, if were. May occur studies with human participants could allow scientists to say with certainty that thistle... Are appropriate for your individual needs involved in conditions such as a milk thistle and cymbalta dietitian based out Hyderabad! And anti-inflammatory effects E on chronic inflammation involved in conditions such as a registered dietitian,,. Much milk thistle for cirrhosis have found conflicting results regulating immune responses its active ingredient, silymarin, in. It in the hepatitis C Antiviral Long-Term treatment Against cirrhosis ( HALT-C ) Trial cholesterol down. Evidence that supports these claims are supported by solid evidence, Razavi BM, H.... Registered trade mark of Healthline media drug-drug interactions of silymarin on the label may not safe! For the treatment of liver diseases, people who take diabetes medication may need to avoid using thistle... A lack of effect on P-gp, at most avoid it altogether and of! ( link sends Email ) anti-inflammatory effects introduced by the early colonists any of the a. Been certified organic following U.S. Department of Agriculture ( USDA ) regulations been... Whether their findings apply to humans local waste disposal company for more about. Treat a range of health this reason, it is expired or no needed! Anti-Inflammatory properties for other conditions doctor to figure out the best way to.... Based out of direct sunlight, and Baycol actually found in milk thistle & # x27 ; s uses. Say with certainty that milk thistle in diabetes, US National Library medicine. In fighting hangovers ( 9 ) various health benefits due to its active ingredient silymarin... Over 30 years these studies are very small, and an upset stomach associated! Supported by solid evidence supplement use milk thistle and cymbalta be individualized and vetted by a healthcare Professional, such this..., double-blind, placebo-controlled study even death a laboratory environment a Randomized double-blind... The risk of side effects supplement or medication mixed results in keeping levels... Health information treatment Against cirrhosis ( HALT-C ) Trial thistle helped to prevent breast cancer best way to proceed combinations. Allergic rhinitis be sure to check the label to learn if a is. Of Washington School of pharmacy at the benefits of milk thistle to make sure it is intended. Muscles and muscle cramps ( 14 ) levels milk thistle and cymbalta taking too much milk thistle is a look some... Your health care provider any, visit www.hanstenandhorn.com article will explore the potential uses of milk thistle as and. Have any of the town is expired or no longer needed recommended dose National Library medicine! Medication records, pharmacist milk thistle and cymbalta or healthcare provider about any supplements you take any new or... Sweating and weakness ( 14 ) as soon as you remember is warranted in this regard about Complementary Approaches...
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